Table 1. The most detrimental and protective factors for four cancers.

Trait	Exposure	IVW			MR-Egger			Weighted median
		OR (95% CI)	P value		OR (95% CI)	P value		OR (95% CI)	P value
Lung cancer	7-alpha-hydroxy-3-oxo-4-cholestenoate	1.45 (1.06–1.97)	0.0184		1.30 (0.74–2.26)	0.3625		1.15 (1.01–1.36)	0.0184
Lung cancer	Pseudouridine	0.50 (0.30–0.83)	0.0070		0.72 (0.17–3.06)	0.6536		0.65 (0.31–1.34)	0.2394
Ovarian cancer	Gamma-glutamylisoleucine	1.40 (1.16–1.69)	0.0004		1.18 (0.80–1.74)	0.4098		1.33 (0.99–1.79)	0.0570
Ovarian cancer	2-methylbutyroylcarnitine	0.77 (0.68–0.86)	2.995E-06		1.17 (0.90–1.53)	0.245		0.63 (0.52–0.0.75)	0.000
Breast cancer	1-oleoylglycerophosphocholine	1.22 (1.1–1.35)	0.0001		1.19 (0.97–1.45)	0.0917		1.17 (1.02–1.34)	0.0273
Breast cancer	2-methylbutyroylcarnitine	0.77 (0.70–0.85)	3.418E-07		1.59 (1.27–1.99)	6.233E-05		1.004 (0.91–1.11)	0.935
Glioma	Gamma-glutamylleucine	4.74 (1.18–18.93)	0.0278		3.18 (0.03–296.7)	0.6193		7.93 (1.03–61.02)	0.0466
Glioma	Glycylvaline	0.13 (0.02–0.75)	0.0217		0.12 (0.0002–87.65)	0.5347		0.09 (0.0071–1.20)	0.0683

IVW, inverse variance weighted; MR, Mendelian randomization.