Table 5. Univariate and multivariate Cox regression analyses for risk scores on the OS of patients with LUAD.
| Parameters | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | ||
| Risk group | |||||||
| High risk | 1 | 1 | 1 | 1 | 1 | 1 | |
| Low risk | 0.3780 | 0.2015–0.7091 | 0.00244** | 0.3898 | 0.1938–0.7842 | 0.00825** | |
| Age | 0.994979 | 0.9685–1.022 | 0.7156 | ||||
| Sex | |||||||
| Male | 0.8182 | 0.448–1.494 | 0.514 | ||||
| Female | 1 | 1 | 1 | ||||
| Tumor status | |||||||
| Tumor free | 1 | 1 | 1 | 1 | 1 | 1 | |
| With tumor | 5.0491 | 2.587–9.856 | 2.09e-06*** | 5.35 | 2.559-11.18 | 8.28e-06*** | |
| Histologic diagnosis | |||||||
| LUAD-NOS | 1 | 1 | 1 | ||||
| LUAD-specified | 0.6688 | 0.3488– 1.282 | 0.226 | ||||
| Residual tumor | |||||||
| R0 | 1 | 1 | 1 | 1 | 1 | 1 | |
| R1 | 4.4435 | 1.6802–11.752 | 0.00265** | 0.8514 | 0.2455–2.954 | 0.7999 | |
| Rx | 2.3276 | 0.7012–7.726 | 0.16755 | 1.329 | 0.3082–5.727 | 0.7030 | |
| Stage | |||||||
| I | 1 | 1 | 1 | 1 | 1 | 1 | |
| II | 2.6297 | 1.187–5.827 | 0.01723* | 1.259 | 0.1988–7.977 | 0.8066 | |
| III | 3.3567 | 1.598–7.049 | 0.00138** | 1.6 | 0.1858–13.79 | 0.6686 | |
| IV | 3.9349 | 1.101–14.066 | 0.03506* | 0.5796 | 0.04838–6.945 | 0.6669 | |
| T | |||||||
| T1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| T2 | 1.486 | 0.7244–3.047 | 0.28009 | 1.15 | 0.5201–2.542 | 0.7303 | |
| T3 | 1.523 | 0.3267–7.098 | 0.59231 | 0.6339 | 0.1138–3.532 | 0.6029 | |
| T4 | 4.979 | 1.5392–16.105 | 0.00736** | 4.459 | 0.9936–20.01 | 0.0509 | |
| Tx | 6.889 | 0–∞ | 0.99750 | – | – | – | |
| N | |||||||
| N0 | 0.3460 | 0.1845–0.6488 | 0.000938*** | 0.645 | 0.1033–4.029 | 0.6390 | |
| N+ | 1 | 1 | 1 | 1 | 1 | 1 | |
| M | |||||||
| M0 | 1 | 1 | 1 | ||||
| M1 | 2.04708 | 0.6187–6.773 | 0.241 | ||||
| Mx | 0.91775 | 0.4546–1.853 | 0.811 | ||||
| Subdivision | |||||||
| L | 1 | 1 | 1 | ||||
| R | 1.09535 | 0.6013–1.995 | 0.766 | ||||
*, P<0.05; **, P<0.01; ***, P<0.001. OS, overall survival; LUAD, lung adenocarcinoma; NOS, not-otherwise-specified; HR, hazard ratio; CI, confidence interval.