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. 2022 Aug 8;12:13550. doi: 10.1038/s41598-022-17767-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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miRNA profile in the BCC and wBCC, as determined by a microRNA sequencing analysis. (A) The principal component analysis (PCA) of BCC and wBCC. (B) The expression of miRNAs in BCC and wBCC presented by a heatmap. (C) The differential expression of miRNAs in BCC and wBCC presented by volcano plot. (D) The key miRNAs were analyzed by least absolute shrinkage and selection operator (LASSO) regression. (E) The Gene Ontology (GO) pathway analysis to determine mRNAs targeted by miRNAs. (F) The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis to determine mRNAs targeted by miRNAs^35–37.