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. 2022 Aug 8;7:47. doi: 10.1038/s41525-022-00319-8

Fig. 6. Ingenuity pathway analysis of synaptosomal miRNAs in AD.

Fig. 6

a Synaptosomal miRNAs expression network in various human diseases. b MiRNAs target and seed sequences network of synaptosomal miRNAs in the AD and healthy state. Red nodes represent increased expression and green nodes represent a decreased expression of miRNAs. c Possible molecular mechanism of miR-501-3 and miR-502-3p in AD progression via negative modulation of GABAergic synapse. Inhibition of GABARA1 expression by the overexpression of these miRNAs could inhibits the GABAergic synapse function in AD.