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. 2022 Aug 8;13(8):694. doi: 10.1038/s41419-022-05145-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Low expression of OTUD1 is a poor prognosis factor in kidney cancer. Kaplan–Meier survival curves of patients with kidney renal clear cell carcinoma (KIRC) with high (n = 258 patients) and low (n = 258 patients) expression of OTUD1 mRNA, determined by the Log-rank test, are shown. b Loss of positive correlation between OTUD1 and KEAP1 in kidney cancer. Correlations of expression levels with Pearson correlations and P-values of OTUD1 vs. KEAP1 (upper panels) or OTUD1 vs. NF-κB1 (lower panels) in normal (left panels) and tumor (right panels) kidney cortex are shown. c Schematic representation of OTUD1 functions in the regulation of inflammatory and KEAP1-mediated oxidative stress responses, and cell death pathways.