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. 2022 Aug 8;13:4628. doi: 10.1038/s41467-022-31629-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Schematic of induction and wounding. b–d Thy1⁺ cell progeny migrate to the wound in a clonal fashion and can be detected at day 60 post wound infliction within the wound site [n = 3 mice]. e At 120 days post wounding, clonal units can be detected in the neo-epidermis that deviate from the regular epidermal proliferative unit (EPU) structure [n = 3 mice]. f Mean number of cornified units per basal clone at 30, 60, and 120 days post induction in homeostatic (unwounded) skin and wound areas [n = 3 mice per time point, 30 clones per mouse]. g Fold difference in number of EYFP-labeled α6^hiSca1^hiThy1^hi SCs following a 14-day chase post induction (0 days), and after 14 days in wounded or unwounded dorsal skin [n = 3 mice per group]. ns (P = 0.778) and ***P = 0.0004 (two-tailed unpaired Student’s t test). All error bars show ±S.E.M. All source data are provided as a Source Data file. Scale bars: 200 μm (b–d), 50 μm (e).