Fig. 8. Cpd16 administration largely ameliorates trabecular bone loss in OVX mice.

The female C57/BL6 mice were subject to bilateral ovariectomy (OVX) procedure. Afterward, Cpd16 (at 5 mg/kg) or PBS were intraperitoneally injected (i.p.) at the first day of each week, and mice were sacrificed after 8 weeks. The representative micro-CT images of trabecular bones and cortical bones were presented (A). BV/TV (%, B) and bone mineral density (BMD, g/cm³, C) of trabecular bones were calculated. BMD of cortical bones was recorded as well (D). The relative SOD activity in the left tibia bone tissues in different groups was shown (E). The control group mice were orally administered with PBS (“Ctrl”). 10 mice per group. ^#P < 0.05.