Table 1.
Summary of QPI drug response parameters.
Name | Abbreviation | Description | Units |
---|---|---|---|
Specific growth rate | SGR | Exponential growth constant, computed as the rate of change of cell mass over time, normalized by cell mass | h−1 |
Half maximal effective concentration | EC50 | Therapy concentration at which cells exhibit 50% of maximum response | µM |
Depth of response | DoR | Maximum difference in SGR between cells at minimum and maximum therapy concentrations, computed from Hill sigmoid curve fitting parameters | - |
Time of response | ToR | The average time required to elicit a response to therapy at the tested concentration | h |
Standard deviation of response | SD | Standard deviations of SGR at the tested concentration as a measure of cell-to-cell heterogeneity | h−1 |