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. 2022 Aug 8;11(1):45. doi: 10.1038/s41389-022-00421-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A–H AMI-1 (Selleckchem, Cat#S7884) and MS023 (MedChemExpress, Cat#HY-19615) suppresses tumor cells metastasis and growth. A, B The protein levels of metastasis-related and proliferation-related markers were measured by western blotting in HeLa and MGC803 cells treated with AMI-1 (10 µM, 24 h) and MS023 (10 µM, 24 h). C, D Transwell assays were performed to test the migratory and invasive potential of the cells above (n = 5, Student’s t-test). Scale bar, 200 µm. E, F MTT (n = 3) and G, H EdU incorporation assays were performed to test the ability of cell growth in the cells above (n = 4, Student’s t-test). I–L G98R suppresses tumor cells metastasis and growth. I The protein levels of metastasis-related and proliferation-related markers were measured by western blotting in HeLa and MGC803 cells transfected with empty vector, PRMT1 or G98R. J Transwell assays were performed to test the migratory and invasive potential of the cells above (n = 4, one-way ANOVA). Scale bar, 200 µm. K MTT (n = 3, one-way ANOVA) and L EdU incorporation assays were performed to test the ability of cell growth in the cells above (n = 4, one-way ANOVA). Date were the mean ± SD. *p < 0.05, **p < 0.01.

Fig. 4 — A–H AMI-1 (Selleckchem, Cat#S7884) and MS023 (MedChemExpress, Cat#HY-19615) suppresses tumor cells metastasis and growth. A, B The protein levels of metastasis-related and proliferation-related markers were measured by western blotting in HeLa and MGC803 cells treated with AMI-1 (10 µM, 24 h) and MS023 (10 µM, 24 h). C, D Transwell assays were performed to test the migratory and invasive potential of the cells above (n = 5, Student’s t-test). Scale bar, 200 µm. E, F MTT (n = 3) and G, H EdU incorporation assays were performed to test the ability of cell growth in the cells above (n = 4, Student’s t-test). I–L G98R suppresses tumor cells metastasis and growth. I The protein levels of metastasis-related and proliferation-related markers were measured by western blotting in HeLa and MGC803 cells transfected with empty vector, PRMT1 or G98R. J Transwell assays were performed to test the migratory and invasive potential of the cells above (n = 4, one-way ANOVA). Scale bar, 200 µm. K MTT (n = 3, one-way ANOVA) and L EdU incorporation assays were performed to test the ability of cell growth in the cells above (n = 4, one-way ANOVA). Date were the mean ± SD. *p < 0.05, **p < 0.01.