Table 2.
Model parameter chosen to be optimized, as well as their upper and lower limits used in the MCMC method
| Parameter (unit) | Upper/lower limits (PACA-Cbz |
Upper/lower limits (LipImage™ 815) | Description |
|---|---|---|---|
| χrich (-) | 1.67 × 10−2–15 | 1.67 × 10−1–150 | Permeability of richly perfused organs |
| P (-) | 3.3 × 10−2–30 | 1.67 × 10−3–1.5 | Tissue-blood partition coefficient |
| kkidneyEl (h−1) | 1–900 | 3.3 × 10−2–30 | Renal elimination rate |
| kab0 (h−1) | 1.16 × 10−2–10.5 | 3.3 × 10−2–30 | The maximum uptake rate of phagocytizing cells in organs except for the spleen |
| ksab0 (h−1) | 1.67 × 10−2–15 | 3.3 × 10−2–30 | The maximum uptake rate of phagocytizing cells in the spleen |
| kde (h−1) | 3.3 × 10−5–0.03 | 3.3 × 10−5–0.03 | The release rate of phagocytizing cells |