Table 2.
Final estimates of population PK parameters
| Parameter | Description | Estimate | %RSE | 1000 Bootstrap replicates (93.6% successful) Median (95% CI) |
|---|---|---|---|---|
| CL/F (L/h) | Apparent oral clearance | 13.2 | 5.0 | 13.1 (11.9–14.5) |
| Q/F (L/h) | Intercompartmental clearance | 3.75 | 20.5 | 3.81 (2.78–5.62) |
| V1/F (L) | Apparent volume of central compartment | 172 | 4.7 | 170 (154–189) |
| V2/F (L) | Apparent volume of peripheral compartment | 43.6 | 10.4 | 44.0 (37.4–54.1) |
| Ka (h−1) | Absorption rate constant | 1.22 | 18.2 | 1.20 (0.829–1.84) |
| MTT (h) | Mean transit time (of the absorption transit compartments) | 0.537 | 14.9 | 0.530 (0.376–0.735) |
| N | Number of transit compartments | 3.62 | 12.1 | 3.60 (2.51–18.3) |
| IIVCL (%) | Interindividual variability of CL | 24.8 | 12.8 | 24.2 (18.3–30.3) |
| IIVV1 (%) | Interindividual variability of V1 | 27.7 | 11.4 | 27.3 (19.9–33.7) |
| IIVKa (%) | Interindividual variability of Ka | 88.3 | 15.7 | 85.1 (52.6–128.6) |
| IIVMTT (%) | Interindividual variability of MTT | 80.5 | 17.3 | 77.4 (40.2–122.2) |
| Prop error (%) | Proportional error | 13.6 | 10.0 | 13.2 (10.6–15.8) |
RSE relative standard error