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. 2022 Jul 14;90(2):125–136. doi: 10.1007/s00280-022-04454-y

Table 4.

Application of the final popPK model from healthy volunteers to patient data

All data Data within one dosing-intervala
PEDV (n = 178) PECL (n = 40) PEDV (n = 85) PECL (n = 35)
Bias (%) 4.6 33.7 − 1.9 27.0
Precision (%) 17.6 36.6 15.2 30.0

Bias: median prediction errors; Precision: median absolute prediction errors. PEDV: prediction error of plasma concentration (Eq. (1)) PECL: prediction error of clearance (Eq. (2))

aSubset of data to minimize the uncertainly of time of drug administration in outpatient treatment of the GIST-patients