FIG. 4.

(A) Comparison of the absolute presence of different leukocyte subpopulations identified by CIBERSORTx between the NIT (dark grey), SFIT (black), and ELIT (light grey) categories. There is a significant increase in the counts of most B and T cell subpopulations and activated NK cells in infiltrated glands, especially in ELIT samples. In addition, the counts of M1 and M2, but not those of M0 macrophages are increased in SFIT and ELIT samples. (B) DEGs associated with the Th1, Th2, and Th17 responses in SFIT and ELIT categories compared to those in NIT glands. Th1 is the predominant CD4 response in infiltrated tissues. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.