TABLE 1.

Frequency of pathogenic GRN mutations with CADD score ≥ 20 in the different cohorts

Dataset	Number of variants	Frequency in affected	Frequency in unaffected
gnomAD exomes (all populations)	127	NA	0.0075
EFIGA families	22	0.0512	0.0473
ROSMAP	8	0.014	0.0082
NACC	30	0.0052	0.0052

Abbreviations: CADD, Combined Annotation Dependent Depletion; gnomAD, Genome Aggregation Database; EFIGA, Estudio Familiar de Influencia Genetica en Alzheimer's; ROSMAP, Religious Orders Study and Memory and Aging Project; NACC, National Alzheimer's Coordinating Center.