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A simple putative mechanism of MIR133A regulation of SOX9-mediated cell proliferation, cell migration, and colony formation in human CRC. Decreased MIR133A expression in CRC cells or tissues leads to upregulation of cellular SOX9 levels. The increased SOX9 level causes activation of downstream pathways, such as PIK3CA-pAKT-GSK3B-CTNNB1, KRAS-BRAF-MAP2K1 (MEK)-MAP2K1/3 (ERK), and apoptosis pathways, resulting in increased colony formation, cell proliferation, and cell migration.
