Skip to main content
. 2022 Jul 15;12(7):3405–3421.

Figure 4.

Figure 4

SHMT2 over-expression affects multiple signaling pathways and biological processes in the breast cancer cells. A. Clustering results of differentially expressed genes comparing ZR-75-1 cells with SHMT2 over-expression with the control group cells. B. Volcanic map of differentially expressed mRNAs. C. GO enrichment histogram of differentially expressed mRNA. D. The methodology of KEGG is conducted according to the literature reported by Kanehisa [20]. KEGG pathway enrichment bars of differentially expressed mRNA. E. Common signaling pathways are closely associated with cell proliferation and survival. F. SHMT2 over-expression affects a variety of biochemical metabolic processes in breast cancer cells. G. SHMT2 over-expression affects the MAPK pathway, apoptosis pathway, and VEGF pathway.