Table 3.
Relationships between the clinicopathological variables and inflammatory ratios calculated for the cohort of 348 OSCC patients.
| Variable | Total No. | NLR Mean (SD) |
p | SII Mean (SD) |
p | LMR Mean (SD) |
p | PLR Mean (SD) |
p |
|---|---|---|---|---|---|---|---|---|---|
| BMI | 321 | -0.114 * | 0.054 | -0.140 * | 0.019 | 0.11 * | 0.063 | -0.131 * | 0.027 |
| Age (years) | |||||||||
|
< 65
≥ 65 |
177 135 |
2.57 (1.80) 2.49 (1.18) |
0.65 | 666.53 (455.23) 604.98 (336.44) |
0.17 | 4.04 (2.76) 3.87 (1.99) |
0.53 | 132.51 (59.84) 139.18 (56.23) |
0.08 |
| Gender | |||||||||
|
Female
Male |
116 196 |
2.46 (1.15) 2.59 (1.76) |
0.44 | 658.49 (373.57) 628.87 (428.46) |
0.54 | 4.15 (1.71) 3.85 (2.81) |
0.30 | 143.53 (55.88) 130.03 (59.14) |
0.31 |
| Tobacco | |||||||||
|
No
Yes |
112 181 |
2.47 (1.11) 2.59 (1.80) |
0.48 | 615.55 (320.71) 655.80 (442.30) |
0.37 | 3.95 (1.97) 4.01 (2.79) |
0.84 | 140.20 (56.00) 132.03 (59.41) |
0.81 |
| Alcohol consumption | |||||||||
|
No
Yes |
155 141 |
2.42 (1.19) 2.62 (1.86) |
0.25 | 584.77 (317.14) 681.55 (459.21) |
0.039 | 4.01 (2.04) 4.01 (2.93) |
0.99 | 134.31 (53.08) 136.08 (62.90) |
0.80 |
| Location of primary tumor | |||||||||
|
Tongue
Floor of the mouth Gingiva Palate Buccal cheek mucosa Retromolar trigone Multicenter |
144 77 61 18 24 22 2 |
2.58 (1.87) 2.37 (1.26) 2.57 (1.32) 2.83 (1.53) 2.59 (1.48) 2.58 (1.00) 1.44 (1.68) |
0.87 | 645.92 (409.32) 601.63 (404.32) 709.17 (484.22) 649.75 (458.42) 584.10 (266.51) 621.37 (263.82) 336.89 (421.64) |
0.72 | 3.77 (1.87) 4.47 (3.55) 3.79 (2.38) 3.54 (1.38) 4.32 (1.87) 3.39 (1.25) 10.59 (5.75) |
0.002 | 140.17 (63.14) 121.86 (53.93) 142.61 (50.44) 139.87 (62.29) 134.55 (65.71) 134.33 (44.36) 0 |
0.001 |
| AJCC pT | |||||||||
|
pT1
pT2 pT3 pT4 |
80 131 42 52 |
2.09 (1.02) 2.44 (1.24) 2.97 (1.14) 3.05 (2.67) |
0.001 | 536.59 (346.73) 579.87 (357.65) 841.22 (401.80) 744.63 (495.79) |
< 0.0005 | 4.49 (2.36) 3.91 (2.01) 3.27 (1.11) 4.03 (3.96) |
0.06 | 123.82 (50.84) 126.07 (52.60) 165.73 (51.28) 152.20 (76.96) |
0.24 |
| AJCC pN | |||||||||
|
pN0
pN+ |
193 107 |
2.46 (1.22) 2.62 (2.00) |
0.37 | 628.05 (384.10) 639.94 (398.37) |
0.80 | 3.94 (2.07) 4.10 (3.12) |
0.58 | 138.47 (59.07) 129.02 (56.24) |
0.10 |
| Stage | |||||||||
|
I
II III IV |
70 89 52 101 |
2.03 (1.04) 2.52 (1.23) 2.74 (1.23) 2.81 (2.11) |
0.009 | 516.28 (352.15) 598.56 (328.90) 694.15 (371.66) 738.41 (497.74) |
0.003 | 4.62 (2.76) 3.84 (1.85) 3.53 (1.45) 3.84 (3.00) |
0.06 | 122.79 (54.21) 132.63 (48.28) 135.22 (50.52) 148.16 (71.55) |
0.37 |
| Postoperative radiotherapy | |||||||||
|
No
Yes |
153 151 |
2.51 (1.33) 2.53 (1.76) |
0.57 | 626.10 (425.25) 647.07 (381.10) |
0.55 | 3.84 (2.11) 4.16 (2.80) |
0.37 | 136.39 (59.47) 127.97 (52.79) |
0.32 |
| Grade | |||||||||
|
Well
Moderate + Poor |
191 121 |
2.44 (1.29) 2.69 (1.91) |
0.17 | 629.15 (425.72) 656.80 (381.03) |
0.56 | 4.08 (2.80) 3.77 (1.77) |
0.27 | 132.71 (58.41) 139.78 (57.77) |
0.45 |
| Clinical status at the end of the follow-up | |||||||||
|
Alive and without recurrence
Dead of index cancer Lost or died of other causes Second primary tumor |
130 120 58 4 |
2.44 (1.15) 2.66 (1.93) 2.56 (1.53) 2.27 (1.68) |
0.71 | 602.56 (326.49) 676.69 (457.15) 636.85 (447.01) 800.10 (699.74) |
0.45 | 4.03 (2.07) 3.98 (2.98) 3.75 (2.07) 4.52 (2.09) |
0.86 | 132.36 (54.21) 134.65 (48.28) 144.11 (50.52) 152.74 (72.79) |
0.13 |
BMI, Body mass index. * Pearson correlation coefficient.