Table 4.

Univariate Cox regression analysis of overall and disease-specific survival in the cohort of 348 OSCC patients.

Variable	Overall survival		Disease-specific survival
	HR (95% CI)	p	HR (95% CI)	p
Age (years)
<65  ≥65	1 (reference) 1.439 (1.086 – 1.908)	0.01	1 (reference) 1.325 (0.948 – 1.852)	0.10
Gender
Female  Male	1 (reference) 1.316 (0.978 – 1.771)	0.06	1 (reference) 1.140 (0.805 – 1.614)	0.46
Tobacco
No  Yes	1 (reference) 1.099 (0.854 – 1.413)	0.60	1 (reference) 1.046 (0.770 – 1.413)	0.77
Alcohol
No  Yes	1 (reference) 1.222 (0.958 – 1.558)	0.07	1 (reference) 1.075 (0.800 – 1.430)	0.62
AJCC pT
pT1  pT2  pT3  pT4	1 (reference) 1.383 (0.936 – 2.045) 2.027 (1.250 – 3.288) 3.519 (2.280 – 5.430)	<0.0001 0.10 0.004 <0.0001	1 (reference) 1.362 (0.835 – 2.220) 2.202 (1.223 – 3.963) 4.477 (2.691 – 7.446)	<0.0001 0.21 0.008 <0.0001
AJCC pN
pN0  pN+	1 (reference) 2.583 (1.938 – 3.442)	<0.0001	1 (reference) 3.158 (2.236 – 4.461)	<0.0001
Stage
I  II  III  IV	1 (reference) 1.377 (0.862 – 2.201) 1.967 (1.203 – 3.215) 3.603 (2.349 – 5.526)	<0.0001 0.18 0.007 <0.0001	1 (reference) 1.594 (0.854 – 2.975) 1.967 (1.431 – 5.059) 5.069 (2.893 – 8.881)	<0.0001 0.14 0.002 <0.0001
Postoperative radiotherapy
No  Yes	1 (reference) 1.422 (1.228 – 1.647)	<0.0001	1 (reference) 1.572 (1.336 – 1.849)	<0.0001
Grade
Well  Moderate + Poor	1 (reference) 1.216 (0.915 – 1.616)	0.17	1 (reference) 1.315 (0.940 – 1.841)	0.11
NLR
≤4.08  >4.08	1 (reference) 1.847 (1.179 – 2.895)	0.007	1 (reference) 1.644 (0.956 – 2.829)	0.07
PLR
≤205  >205	1 (reference) 1.465 (0.908 – 2.363)	0.11	1 (reference) 1.617 (0.939 – 2.784)	0.08
SII
≤1,137  >1,137	1 (reference) 1.979 (1.260 – 3.108)	0.003	1 (reference) 1.479 (0.829 – 2.638)	0.18
LMR
≤4.58  >4.58	1 (reference) 0.668 (0.466 – 0.957)	0.02	1 (reference) 0.665 (0.426 – 1.036)	0.07