Figure 1.

Whole blood DNA methylation levels of cg07454584 (approximately 34 kb downstream of KCNK17) and cg23833119 (located on intron 1 of KCNK17) with respect to 3 genotypes of rs2815063 at the 6p21.2 locus. Boxplots in (A) and (B) show beta values (ratio of methylated to unmethylated probe intensities) of cg07454584 and cg23833119 among 1651 childhood cancer survivors of European ancestry, and those in (C) and (D) show results in 263 survivors of African ancestry. Results from linear regression models examining associations of cg07454584 and cg23833119 with rs2815063 (additively coded), adjusted for age at sample collection and sex are shown on top of each boxplot. P values were 2-sided based on linear regression. FDR = false discovery rate.