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. 2022 Jul 26;13:909123. doi: 10.3389/fphar.2022.909123

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Copyright © 2022 Zhang, Song, Dai, Wang, Zeng, Chen and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of ER stress-related clusters of ccRCC. (A) Consensus cluster matrix of ccRCC samples when k = 2. (B) CDF curves for k = 2–9. (C) PAC scores recorded at different K values. (D) Heatmap of ER stress-related genes and distribution of clinical parameters between two clusters. (E) Distribution of the T stage in the two clusters. (F) Distribution of the TNM stage in the two clusters. (G) Distribution of tumor grade in the two clusters. (H) Expressions of ATF6, PERK, and IRE1α in the two clusters. (I) PCA for two ER stress-related clusters. (J) OS of two ER stress-related clusters. ^∗ p < 0.05, ^∗ ^∗ p < 0.01, ^∗ ^∗ ^∗ p < 0.001.