Table 1.
Discarded liver donor demographics.
| EmricasanN=5 | AHFN=6 | IHFN=5 | AHF vs. IHF P-value | |||||
|---|---|---|---|---|---|---|---|---|
| Liver # | EM1 | EM2 | EM3 | EM4 | EM5 | |||
| DCD? | Y | Y | Y | Y | Y | 6 (100%) | 5 (100%) | |
| tWIT | 22 | 23 | 32 | 23 | 53 | 27.5 (24–28) | 24 (23-34) | 0.93 |
| fWIT | 9 | 8 | 7 | 12 | 13 | 8.5 (8-10) | 11 (9-11) | 0.36 |
| CIT | 347 | 553 | 758 | 703 | 679 | 625.5 (458-697) | 358 (357-367) | 0.082 |
| Age | 28 | 26 | 60 | 50 | 59 | 58.5 (40-60) | 56 (55-59) | 0.85 |
| Gender | M | M | F | F | F | 5M, 1F | 2M, 3F | 0.24 |
| BMI | 38.7 | 19.8 | 31.2 | 28.3 | 31.9 | 26 (24.5-28.3) | 32.9 (29.9-40.2) | 0.068 |
| Weight (kg) | 129.5 | 61.7 | 90.5 | 74.9 | 84.8 | 80.6 (77.6-87) | 90.9 (74.1-100) | 0.86 |
| Macrosteatosis | 30 | 0 | 2 | 0 | 0 | 3.5 (0-5) | 35 (0-40) | 0.35 |
| Microsteatosis | 10 | 5 | 0 | 30 | 0 | 3.8 (0-50) | 5 (0-55) | 0.85 |
| AST | 32 | 38 | 134 | 78 | 27 | 41.5 (39-57) | 98.5 (41.5-366) | 0.39 |
| ALT | 22 | 27 | 40 | 47 | 32 | 32.5 (22-58) | 100.5 (25.5-317.5) | 0.52 |
| Total bilirubin | 1.2 | 0.8 | 0.6 | 0.2 | 0.2 | 0.75 (0.4-1) | 0.35 (0.25-0.45) | 0.086 |
| ALP | 72 | 48 | 76 | 104 | 83 | 58 (36-95) | 99 (94-494) | 0.12 |
| DRI | 1.74 | 1.47 | 3.56 | 3.04 | 2.83 | 2.05 (1.9-2.2) | 2.4 (2.2-2.4) | 0.14 |
Median with interquartile range shown for continuous data. Wilcoxon rank-sum test or Fisher’s exact test used for group comparisons. AHF, adequate hepatocellular function group; IHF, inadequate hepatocellular function group; DCD, donation after circulatory death; tWIT, total warm ischemic time (extubation to cold flush) in minutes; fWIT, functional warm ischemic time (asystole to cold flush) in minutes; CIT, cold ischemia time in minutes; BMI, body mass index (kg/m2); steatosis expressed in percentages; DRI, donor risk index. Terminal values prior to procurement shown for AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase).