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. 2022 Jul 26;10:915785. doi: 10.3389/fcell.2022.915785

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Copyright © 2022 Wang, Mang, Li, Cai and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of CAP_PZ2 treatment on the migratory and invasive ability of the HT29 and A549 cells. The HT29 (A) and A549 (B) cells were treated by CAP_PZ2 for 30 and 60 s, incubated for 24 h, before subjected to Transwell migration and Matrigel invasion assays. Representative images (left) and statistics (right) of migration and invasion assay were shown. The scale bar equals 200 μm. The experiments were performed in triplicates. (C,D) mRNA (MMP9, MMP2, VEGF, MTDH) expression changes during CAP_PZ2 treatment with different time. *p < 0.05, **p < 0.01, and ***p < 0.001 versus control, n = 3.