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. 2022 Jul 26;10:915785. doi: 10.3389/fcell.2022.915785

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Copyright © 2022 Wang, Mang, Li, Cai and Tan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo CAP_PZ2 treatment of mouse xenograft tumors. (A) Flowchart of in vivo CAP_PZ2 therapy regimen. (B) Photograph of an operating Piezobrush^® PZ2 CAP device irradiating tumors on a nude mouse bearing the HT29 or A549 cells. (C) Pathological specimens of resected in situ tumors with and without CAP_PZ2 treatment. (D) Tumor growth curves of mice xenografts during the entire course of CAP_PZ2 treatment. (E) Tumor weight after the last dose of plasma administration (*p < 0.05, **p < 0.01, ***p < 0.001, n = 8). (F) Representative histological images characterizing tumours and Immunohistochemical analysis using antibodies against various apoptosis-related proteins. Scale bar = 50 μm.