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. 2022 Jul 26;13:893561. doi: 10.3389/fphar.2022.893561

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Copyright © 2022 Luo, Zhang, Pan, Gu, Tan and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AEPE treatment affected the diversity in CDAHFD mice. (A) Rarefaction curve flattened out indicated that the sequencing depth has basically covered all the species in the sample. (B) Rank abundance indicated that the libraries were large enough to cover most of the bacterial diversity in each sample. (C) PCoA indicated more similar beta diversity between the AEPE-M and control groups than that between the CDAHFD and control groups. (D,E) Simpson’s and Shannon’s indexes were higher in the CDAHFD group than in the control group. (F,G) There were no significant differences in the Chao 1 index and the Ace index in each group. Control, CDAHFD, and AEPE-M (n = 6 per group) groups. Data are presented as the mean ± SEM. ^## p < 0.01 as compared to the control group.