FIGURE 1.

Oroxylin A exhibited potential of being an antidepressant candidate in the FST and TST. A single treatment of vehicle, paroxetine (20 mg/kg) or oroxylin A (1, 2, 5 and 10 mg/kg) was given to naïve C57BL/6J mice, and after 30 min, the FST, TST or OFT was conducted. (A) Oroxylin A and paroxetine significantly reduced the immobility duration of naive mice in the FST. (B) Oroxylin A and paroxetine notably decreased the immobility duration of naive mice in the TST. (C) Neither oroxylin A nor paroxetine induced significant effects on the locomotor activity of naive mice in the OFT. All data are displayed as means ± S.E.M. (n = 12); ^** p < 0.01 vs. Vehicle. The statistical comparisons were achieved by (One-way ANOVA + Tukey’s test).