TABLE 1.
Two-component systems in B. subtilis
| Classa | Familyb | Kinase | Response regulator | Organizationc | Adaptive role |
|---|---|---|---|---|---|
| I | Others-B | LytS | LytT | HR | Rate of autolysis |
| YesM | YesN | HR | Unknown and nonessential | ||
| YwpD | Orphand | Unknown and nonessential | |||
| II | NarL | DegS | DegU | HR | Degradative enzyme and competence |
| YhcY | YhcZ | HR | Unknown and nonessential | ||
| YvqE | YvqC | HR | Unknown and nonessential | ||
| YvfT | YvfU | HR | Unknown and nonessential | ||
| YocF | YocG | HR | Unknown and nonessential | ||
| YdfH | YdfI | HR | Unknown and nonessential | ||
| YxjM | YxjL | HR | Unknown and nonessential | ||
| YfiJ | YfiK | HR | Unknown and nonessential | ||
| ComP | ComA | HR | Early competence | ||
| IIIA | OmpR | YcbM | YcbL | RH | Unknown and nonessential |
| YxdK | YxdJ | RH | Unknown and nonessential | ||
| YtsB | YtsA | RH | Unknown and nonessential | ||
| YvcQ | YvcP | RH | Unknown and nonessential | ||
| YbdK | YbdJ | RH | Unknown and nonessential | ||
| YvqB | YvqA | RH | Unknown and nonessential | ||
| YkoH | YkoG | RH | Unknown and nonessential | ||
| YrkQ | YrkP | RH | Unknown and nonessential | ||
| YclK | YclJ | RH | Unknown and nonessential | ||
| YvrG | YvrH | RH | Unknown and nonessential | ||
| YycG | YycF | RH | Essential functions | ||
| ResE | ResD | RH | Aerobic and anaerobic respiration | ||
| PhoR | PhoP | RH | Alkaline phosphatase and phosphodiesterase | ||
| YccG | YccH | RH | Unknown and nonessential | ||
| IIIB | NtrB | KinA | Spo0F | Orphan | Initiation of sporulation |
| KinB | Spo0F | Orphan | Initiation of sporulation | ||
| KinC | Orphan | ||||
| YkvD | Orphan | ||||
| YkrQ | Orphan | ||||
| IV | Others-A | YufL | YufM | HR | Unknown and nonessential |
| YdbF | YdbG | HR | Unknown and nonessential | ||
| CitS | CitT | HR | Mg2+/citrate transport | ||
| YcbA | YcbB | HR | Unknown and nonessential | ||
| V | CheY | CheA | CheY | RH | Chemotaxis |
a
Classes defined by comparing the B. subtilis kinases around the histidine.
b
Families of two-component systems defined in E. coli by comparing the response regulator C-terminal domains.
c
Organization of each kinase-regulator pair on the B. subtilis chromosome (HR, 5′ histidine kinase-3′ response regulator; RH, 5′ response regulator-3′ histidine kinase).
d
“Orphan” designates an histidine kinase gene not directly associated with a response regulator gene in an operon on the chromosome.