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. 2022 Jul 15;14(7):5014–5023.

Figure 4.

Figure 4

Effect of repeated (7 days) administration of ESAF with ARS [(50, 100, 250 mg/kg and combination group p.o (EASF 50 mg/kg+Imipramine 5 mg/kg)+ARS] on plasma corticosterone levels. Each column represents the mean ± S.E.M. Statistical analysis was performed by one-way ANOVA, followed by Dunnet’s multiple comparison test. *P<0.05, **P<0.01, **P<0.001 as compared to ARS control group. Plasma corticosterone levels of acute restrained mice with ESAF treatments for 7 consecutive days reverse significantly [F (6, 35) = 15.05, P<0.0001] the increased plasma corticosterone levels. ESAF 50 mg/kg showed not significant (P<0.2400) effect compared to ARS control group but was significant when compared to the control group. While EASF 100 & 250 mg/kg showed significant (P<0.0116 & 0.0029) effect when compared to ARS control, the combination group showed highly significant effect (P<0.0003) comparable to the ARS control group. ARS: Acute restraint stress; ESAF: Ethanolic Extract of S. asoca Flowers.