Effect of repeated (7 days) administration of ESAF with ARS [(50, 100, 250 mg/kg and combination group p.o. (EASF 50 mg/kg+Imipramine 5 mg/kg) + ARS]. Each column represents the mean ± S.E.M. Statistical analysis was performed by one-way ANOVA, followed by Dunnet’s multiple comparison test. *P<0.05, **P<0.01, **P<0.001 as compared to ARS. EASF for seven days significantly increased the activity of SOD enzyme in the hippocampus of mice subjected to ARS F [(6, 35) = 32.33, P<0.001)] in corresponds to Dunnet’s comparison test revealed ESAF 100 mg/kg (P<0.025) and 250 mg/kg P<0.040) significantly increased the activity of SOD. The combination group showed even more significance (P<0.001) when compared to the other two doses. ARS: Acute restraint stress; ESAF: Ethanolic Extract of S. asoca Flowers.