Figure 5.

Orientation tuning diversity of dendritic spine populations in ferret V1 match simulations with correlated, heterogeneous input populations. (A) Two-photon standard deviation projection of example dendrite and spines recorded from a single cell (left). Inset: Two-photon standard-deviation projection of corresponding soma. The scale bar is 10 microns. Orientation tuning of soma (top) and all visually-responsive dendritic spines from this single cell (n = 159) are shown (right). Spine responses are normalized peak ΔF/F. Orientation preferences are shown relative to the somatic preference (aligned to 0^o). (B) Same as in (A) for another example cell (n = 162 visually-responsive spines). (C) Cumulative distributions of tuning correlation between individual dendritic spines or simulated synaptic inputs with corresponding somatic tuning or decoder output. Shown are correlations of simulations of homogenous (blue) or heterogeneous (red) input populations, compared to empirical data (gray). (D) Distributions of average tuning correlation between synaptic input and somatic output across measured cells (n = 45). Also shown are distributions of average tuning correlation for simulated cells. Triangles denote median values for each distribution. (E) Comparison of Kullback-Leibler divergence (D_KL) between data and each model type. Each data point represents an individual cell’s population of dendritic spines.