Table 1.
Clinical, Cytogenetic and Molecular Characteristic in 51 Children and Adults with de novo Acute Myeloid Leukemia According to the Presence or Absence of TET2 Mutations
| Variant | All (n=51) |
TET2mut (n=8) |
TET2wt (n=43) |
p |
|---|---|---|---|---|
| Median age, y (range) | 33.8 (2-79) | 49.6 (22-79) | 30 (2-76) | 0.04 |
| Age in groups (percentage) | 0.52 | |||
| <15 | 13 | 0 | 13 (30) | |
| 16-56 | 21 | 5 (63) | 16 (37) | |
| 56-85 | 13 | 3 (37) | 10 (23) | |
| Sex | 0.48 | |||
| Female | 22 | 3 (30) | 19 (46.3) | |
| Male | 29 | 5 (70) | 24 (53.6) | |
| Laboratory data (range) | ||||
| WBC, 103/µL |
49.8 (1-234) | 26.9 (2.1-77.9) | 55.4 (1-234) | 0.112 |
| Hemoglobin, g/dL | 7.92 (3-13) | 9.47 (6.2-13) | 7.54 (3-11.3) | 0.02 |
| Platelets, 103/µL | 81.9 (11-385) | 55.0 (13-169) | 88.5 (11-385) | 0.39 |
| FAB Classification (percentage) | 0.44 | |||
| M0 | 2 (3.9) | 0 | 2 (5) | |
| M1 | 10 (19.6) | 3 (38) | 7 (16) | |
| M2 | 11 (21.5) | 0 | 11 (26) | |
| M3 | 8 (15.6) | 1 (12) | 7 (16) | |
| M4 | 12 (23.5) | 2 (25) | 10 (23) | |
| M5 | 6 (11.7) | 2 (25) | 4 (9) | |
| M6 | 2 (3.9) | 0 | 2 (5) | |
| Cytogenetics (percentage) | 0.44 | |||
| Favorable | 13 (2505) | 1 (12.5) | 12 (28) | |
| Intermediate | 32 (62.7) | 7 (87.5) | 25 (58) | |
| Unfavorable | 4 (7.8) | 0 | 4 (9) | |
| Missing | 2 (3.1) | 0 | 2 (5) | |
| NPM1 (percentage) |
12 (23.5) | 0 | 12 (28) | 0.09 |
| FLT3-ITD (percentage) | 14 (27.4) | 1 (12) | 13 (30) | 0.25 |
| CEBPA (percentage) |
16 (31.3) | 2 (38) | 14 (32) | 0.6 |
| WT1 (percentage) |
4 (7.8) | 1 (12) | 3 (7) | 1 |