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. 2022 Jul 22;10:908848. doi: 10.3389/fbioe.2022.908848

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Copyright © 2022 Kahn-Krell, Pretorius, Guragain, Lou, Wei, Zhang, Qiao, Nakada, Kamp, Ye and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TEM assessments of the ultrastructure of C1, C3, and C4 spheroids. (A) Whole C1, C3, and C4 spheroids on day 60 were sectioned and imaged via TEM (bar = 2 μM for the top row, and bar = 1 μM for the bottom row); ZL: Z-line, ML: M-line, MT: mitochondria, GJ: gap junction, N: nucleus. (B) Sarcomere lengths were calculated by measuring the distance between adjacent Z-lines. (C) Sarcomere widths were measured as the length of each uninterrupted Z-line. (*p < 0.05, **p < 0.01, ***p < 0.001; n > 5 spheroids per group).