Table 3.
The regulatory role of necroptosis related genes in ovarian cancer progression.
| Target | Mechanism | Function | Reference |
|---|---|---|---|
| AEZS-126 | Target PI3K/AKT | Induce necroptosis and reduce platinum resistance | (156) |
| IAPs | Target TNF-α | Induce necroptosis and promote ovarian cancer | (157) |
| CD40L | Target caspase-3 | Induce necroptosis and promote ovarian cancer | (158) |
| BMI1 | Target PINK1-PARK2 | Induce necroptosis and promote ovarian cancer | (159) |
| Caspase8 | Target NF-κB and RIPK1 | Suppress necroptosis and inhibit ovarian cancer | (160) |
| Luteal-phase progesterone | Target TNF-a/RIPK1/RIPK3/MLKL | Suppress necroptosis and inhibit ovarian cancer | (161) |
| CNL | Target MLKL | Induce necroptosis and promote ovarian cancer | (162) |
| DEBIO 1143 | Target cIAP1, XIAP, and caspase-9 | Induce necroptosis and promote ovarian cancer | (163) |
| ALDH1Ai | / | Induce necroptosis and promote ovarian cancer | (164) |
| CuS–MnS2 | / | Suppress necroptosis and inhibit ovarian cancer | (165) |
| Berberine | Target Caspase-3, Caspase-8, RIPK3, and MLKL | Induce necroptosis and promote ovarian cancer | (166) |
| RIP1 | Target ROS | Induce necroptosis and promote ovarian cancer | (167) |