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. Author manuscript; available in PMC: 2022 Aug 9.
Published in final edited form as: Cancer Res. 2020 Aug 31;80(20):4476–4486. doi: 10.1158/0008-5472.CAN-20-0977

Figure 2.

Figure 2.

Landscape of mutations and copy-number alterations in 62 HGT1 bladder cancer samples. Top to bottom: (i) Overall mutation burden, mutations per MB, top row. (ii) Normalized activity of five mutational signatures (two samples with highest COSMIC1 activity actually belong to COSMIC6). (iii) Clinical features, including outcome, squamous histology, micropapillary histology, pT1b, and gender; black, presence of the feature. (iv) Somatic mutations in SMGs with frequency ≥4.8%. (v) Focal CNA for selected genes. (vi) Chromosome arm level CN events.