Fig. 8: Representative images of VAX1 immunohistochemistry.
Nuclear staining was observed in all SEGAs (a) and focal staining was seen in abnormal clusters of neurons, consistent with balloon neurons in cortical tubers (b). Occasional examples of subependymoma displayed focal nuclear positivity (c), and a single PXA showed positive staining in large pleomorphic tumor cells (e). No nuclear immunoreactivity was noted in ganglioglomas (d), oligodendrogliomas (f), astrocytomas (g), glioblastomas (h), or in normal infant cortex (i). Scale bar: 400 μm, PXA: Pleomorphic xanthoastrocytoma.