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. 2022 Jul 31;7(3):197–204. doi: 10.1016/j.ncrna.2022.07.004

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — Circulating ciRS-7 as an independent prognostic factor for lymph node and distant metastasis status and Receiver Operating Characteristic (ROC) curve analysis based on the preoperative circulating ciRS-7-based signature in the lymph node metastasis cohort and distant metastasis cohorts. (A) Relative circulating ciRS-7 expression level was statistically significantly higher in EOC plasma samples of the positive lymph node metastasis group (n = 51), (B) in EOC plasma samples of the positive metastasis to liver group (n = 29) and (C) in EOC plasma samples of the positive metastasis to lung group (n = 14) than in the negative without metastasis group (n = 60). Circulating ciRS-7 was able to differentiate patients with (D) lymph node metastasis, (E) metastasis to liver and to lung (F) from EOC patients without metastasis (negative).