Impact of drug condition and group on valence-dependent activity in a priori regions of interest. (A) smokers postnicotine (smokers+NIC) vs. (B) postplacebo (smokers+PBO) vs. control subjects. (C, D) Smokers+NIC vs. control subjects. A priori contrasts p < 0.001/pCORRECTED < 0.05 **between conditions, ##between groups. Error bars show ± 1 SE. Activations are rendered on the ICBM452 T1 template from AFNI (60). ACC, anterior cingulate cortex; BA, Brodmann’s area; NAcc, nucleus accumbens; SFG, superior frontal gyrus.