Date	Event	Description
21 April 2022	New citation required and conclusions have changed	Despite a larger number of studies included in the current version of the review, the conclusions have not substantially changed compared to previous versions (Bradley 2002; Bradley 2008; Radtke 2015; Radtke 2017). Nevertheless, the current review extends our knowledge of clinically relevant and patient‐centred outcomes, including adverse events and glycaemic control. Moreover, our certainty in the beneficial effects of regular physical activity and exercise training on aerobic exercise capacity has strengthened, while there were no beneficial effects on lung function and health‐related quality of life (Bradley 2002; Bradley 2008; Radtke 2015; Radtke 2017).
21 April 2022	New search has been performed	A search of the Cochrane Cystic Fibrosis and Genetic Disorders Group's Cystic Fibrosis Trials Register identified 113 references which were potentially eligible for inclusion in this updated review. Two references (abstracts) were identified through other sources. Additional searches of online databases identified a further 505 references (clinicaltrials.gov: 369 references; the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP): 136 references). After initial screening and the removal of duplicates, we assessed 100 new references. Included studies Four new references to three unique studies have been included (Alexander 2019; Donadio 2020; Hatziagorou 2019), and there were 10 new references for five already included studies (Carr 2018; Douglas 2015; Hebestreit 2010; Hommerding 2015; Santana‐Sosa 2014). There were six references for two studies previously listed as ongoing but now included (Gupta 2019; Sawyer 2020), and one reference for a further study previously listed as ongoing under the study ID Hebestreit 2016. This study has now been included and renamed Hebestreit 2022. We found two new references for studies listed as "awaiting classification" as clinical trials registry entries, which have now been included (Del Corral 2018; Güngör 2021). There were also three new references for a further study previously listed as "awaiting classification" under the study ID Lorenc 2015. This study has now been included and renamed Carr 2018. One study, previously listed as ongoing under the study ID Donadio 2017, has been confirmed to be related to the included study Hommerding 2015 and the 2017 reference has been added to the Hommerding 2015 study ID. Excluded studies 59 references to 35 new studies have been excluded with reasons (ACTRN12620001237976; Bass 2019; Bellini 2018; Cantin 2005; Combret 2018; Combret 2021; Cox 2013; de Marchis 2017; Dwyer 2019; Gruber 1998; Hütler 2002; IRCT20161024030474N4; Kaak 2011; Kaltsakas 2021; Lang 2019; Macleod 2008; Martinez Rodriguez 2017; Montero‐Ruiz 2020; Moola 2017; NCT00129350; NCT01759342; NCT02199340; NCT03420209; NCT04888767; NTR2092; Pryor 1979; Radtke 2018b; RBR‐34677v; RBR‐5g9f6w; Reuveny 2020; Ruddy 2015; Spoletini 2020; Ward 2018; White 1997; Young 2019; Zeren 2019). There were five new additional references to already excluded studies (Dwyer 2011; Falk 1988; Lima 2014; Reix 2012; Zeren 2019). Seven studies, previously listed as awaiting classification were excluded: investigators of three studies (with one new reference to one study) informed us that no paper will be published (Happ 2013; Mandrusiak 2011; NCT00792194); the investigators of one study did not reply to our email (Oliveira 2010); and for four studies, no contact details could be found online to contact study investigators (Almajan‐Guta 2011; Housinger 2015; Johnston 2004; Phillips 2008). Ongoing studies Two new studies (Curran 2020; Monteiro 2019), and 10 trial registry records have been added to "ongoing studies" (ISRCTN92573472; NCT03273959; NCT03970369; NCT04249999; NCT04543929; NCT04683809; NCT04742049; NCT05147285; NCT05173194; NCT05239611).  Studies awaiting classification There were three new references for two studies already (and still) listed as "awaiting classification" (Cox 2019; Powers 2016), and two records were added from the trials registry searches (IRCT20190407043190N1; NCT04293926). We identified three new references to a further study that was previously listed as ongoing under the ID NCT02700243; this study has been completed and was added to "awaiting classification" (Bishay 2017). Online trials registry searches A search of Clinicaltrials.gov on 4 March 2022 identified 236 study records (after removal of 129 duplicates). Of these, 191 were physical activity interventions and were disregarded without further assessment (not listed in the review); 19 records had already been identified and listed in this review; 18 records were not randomised controlled trials (i.e. observational studies with single‐group assignment); in five studies the control group was not eligible for this review ('no physical activity intervention'); and three registered studies were prematurely terminated by the investigators.  A search of the WHO International Clinical Trials Registry Platform (ICTRP) on 16 March 2022 identified 136 records to 134 unique studies, none of which were new studies.  In summary, in this 2022 update we have included five new studies (Alexander 2019; Del Corral 2018; Donadio 2020; Güngör 2021; Hatziagorou 2019), one additional study previously listed as "awaiting classification" (Carr 2018), and three studies previously listed as ongoing (Gupta 2019; Hebestreit 2022; Sawyer 2020). We have also excluded 35 new studies (ACTRN12620001237976; Bass 2019; Bellini 2018; Cantin 2005; Combret 2018; Combret 2021; Cox 2013; de Marchis 2017; Dwyer 2019; Gruber 1998; Happ 2013; Hütler 2002; IRCT20161024030474N4; Kaak 2011; Kaltsakas 2021; Lang 2019; Macleod 2008; Martinez Rodriguez 2017; Montero‐Ruiz 2020; Moola 2017; NCT01759342; NCT02199340; NCT03420209; NCT04888767; NTR2092; Pryor 1979; Radtke 2018b; RBR‐34677v; RBR‐5g9f6w; Reuveny 2020; Ruddy 2015; Spoletini 2020; Ward 2018; White 1997; Young 2019; Zeren 2019), added 12 new studies to "ongoing studies" (Curran 2020; ISRCTN92573472; Monteiro 2019; NCT03273959; NCT03970369; NCT04249999; NCT04543929; NCT04742049; NCT04683809; NCT05147285; NCT05173194; NCT05239611), and added three studies to "awaiting classification" (Cox 2019; IRCT20190407043190N1; NCT04293926).