Date	Event	Description
1 November 2017	Amended	Formatting issues resolved
19 October 2017	New citation required but conclusions have not changed	Despite the inclusion of two new studies our conclusions remain the same.
19 October 2017	New search has been performed	A search of the Cystic Fibrosis and Genetic Disorders Review Group's Cystic Fibrosis Trials Register identified 38 new references which were potentially eligible for inclusion in the review. There was one additional reference to an already included study (Schneiderman‐Walker 2000) and six additional references to five already excluded studies (Amelina 2006; del Corral Nunez‐Flores 2014; Kuys 2011; Lima 2014; Salonini 2015). Six references to two new studies has been included (Beaudoin 2017; Douglas 2015) and seven references to five new studies are listed as 'Awaiting classification' (Housinger 2015; Johnston 2004; Carr 2018a; Mandrusiak 2011; Oliveira 2010). One study with two references is ongoing (Hebestreit 2022) and a total of 16 references to 13 new studies have been excluded (Bieli 2017; Bongers 2015; Calik‐Kutukcu 2016; Chang 2015; Dwyer 2017; Giacomodonato 2015; Haynes 2016; Kriemler 2016; Ozaydin 2010; Patterson 2004; Shaw 2016; Vallier 2016; Wheatley 2015). A search of clinicaltrials.gov identified 11 additional studies. Five studies were added to 'Awaiting classification' (NCT00609050; NCT00792194; NCT02552043; NCT03100214; Powers 2016), one study was added under ongoing studies (Bishay 2017a) and five studies were excluded (NCT02277860; NCT02715921; NCT02821130; NCT03117764; NCT02875366). A search of the WHO ICTRN identified three additional studies; one is listed as awaiting classification (ACTRN12617001009303) and two have been added under ongoing studies (Donadio 2017; Gupta 2017a). From this update we have stated a minimum duration of the intervention as being at least two weeks.
15 June 2015	New citation required but conclusions have not changed	Two authors from the original review have stepped down at this update and a new team of authors have taken on the review. The title of the review has been changed from 'Physical training for cystic fibrosis' to 'Physical exercise training for cystic fibrosis' as the new team felt this better reflected the content of the review. Despite the inclusion of new studies and data in this update of the review, the conclusions remain the same.
15 June 2015	New search has been performed	A search of the Cystic Fibrosis and Genetic Disorders Group's Cystic Fibrosis Register identified 32 new references which were potentially eligible for inclusion in this review. Three new studies (one reference each) were included (Rovedder 2014; Santana‐Sosa 2012; Santana‐Sosa 2014). Two studies previously listed as excluded have been reassessed and moved to included studies with two new references each (although one paper referred to both studies) (Hebestreit 2010; Kriemler 2013). One study has been moved from 'Awaiting classification' to included studies with an additional two references (Hommerding 2015). One was an additional reference to an already excluded study (Kuys 2011). A total of 14 new studies (20 references) were excluded (Alarie 2012; Amelina 2006; Asher 1982; Balfour Lynn 1998; del Corral Nunez‐Flores 2014; Dwyer 2011; Gruet 2012; Lima 2014; Lowman 2012; Petrovic 2013; Rand 2012; Reix 2012; Salonini 2015; Vivodtzev 2013). One study (one reference) has been listed as 'Awaiting classification' until we are able to obtain further information (Almajan‐Guta 2011).
22 May 2012	Amended	Contact details updated.
7 March 2011	New search has been performed	A total of two new references were identified in a search of the Group's CF Trials Register. One study was excluded as it compared Nintendo Wii exercise training to an existing exercise programme and hence did not meet the inclusion criteria (Kuys 2011). The other study did meet the inclusion criteria but outlined in its abstract that recruitment was ongoing and for this reason it has been listed as an ongoing study; results will be included in the review once the study has been completed (Phillips 2008a). In addition some amendments were made to the Background in order to incorporate updated guidelines and a relevant survey.
19 January 2009	Amended	The fourth primary outcome 'mortality' was moved to Secondary outcomes in line with Cochrane Collaboration guidance to limit the number of primary outcomes to three.
5 January 2009	New search has been performed	A search of the Group's Cystic Fibrosis Trials Register did not identify any references to trials which are potentially eligible for inclusion in this review.
12 November 2008	Amended	Converted to new review format.
14 November 2007	Amended	The generic inverse variance method has been used to analyse data which were previously not able to be presented in the 'Statistical Analysis'. The 'Synopsis' has been replaced by a new 'Plain Language Summary'.
14 November 2007	New search has been performed	The search identified 11 new references. Of these, two were additional references to already excluded studies (Albinni 2004; Edlund 1986). The remaining nine studies did not fulfil the inclusion criteria; four of these studies which seemed eligible from the title, have been excluded on the basis of trial design and are listed under 'Excluded studies' (Acquino 2006; Balestri 2004; Orenstein 2004; Stanghelle 1998). The study which was previously listed as 'Awaiting assessment' has been moved to the list of excluded studies after correspondence with the study authors (Hebestreit 2003).
13 November 2007	New citation required and conclusions have changed	Substantive amendment
25 May 2005	New search has been performed	A further article has been included (Klijn 2004). The full paper of the trial by Moorcroft (Moorcroft 2004) has also been included. Following publication of this paper, the details about the published abstracts of this trial, previously listed in the 'Characteristics of included studies' table, under Dodd 1998 and Moorcroft 2000 have been listed under Moorcroft 2004. We contacted authors of trials already included in the review regarding confirmation of data and requests for additional data. Their responses have been included in section detailing the search strategy. One trial has been moved from the 'Studies awaiting assessment' section to the 'Excluded studies' section of the review (Tuzin 1998). One trial has been added to the section 'Studies awaiting assessment' section (Hebestreit 2003). The authors have been contacted and have indicated that this study is in preparation for publication.
31 July 2003	Amended	The presentation of the data in MetaView has been re‐formatted.
31 July 2003	New search has been performed	The full paper of the Selvadurai trial has now been included, previously only the abstract of this trial was included in the review (Selvadurai 2002). A further two trials added to the 'Excluded studies' section of the review (Barry 2001; Kriemler 2001).