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. 2022 Aug 9;2022(8):CD002768. doi: 10.1002/14651858.CD002768.pub5

Alexander 2019.

Study characteristics
Methods Design: single‐centre, parallel RCT  
Location: no details given on hospital, city or country
Inclusion criteria: not specified
Exclusion criteria: not specified
Duration: 12 weeks
Participants 15 prepubertal children with CF, mean age 7.94 (SD 1.35) years
Intervention group (n = 9): no further details available
Control group (n = 6): no further details available
Interventions 12‐week, home‐based, whole body vibration exercise training programme
Intervention group: 12‐week, home‐based, whole body vibration training programme (5 times per week for 20 min) combined with their regular airway clearance therapy regimen. 
Control group: usual airway clearance therapy regimen.
Outcomes Primary outcome
  1. Change in total body lean body mass (DEXA) from baseline to 12 weeks


Secondary outcomes
  1. Change in quality of life from baseline to 12 weeks

  2. Change in bone parameters from baseline to 12 weeks

  3. Change in spirometry indices from baseline to 12 weeks

Notes Study reported as an abstract and, therefore, the information was limited.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Described as randomised, but no details given for sequence generation.
Allocation concealment (selection bias) Unclear risk Not discussed.
Blinding of participants and personnel (performance bias)
All outcomes High risk Not possible to blind participants to intervention. Unclear whether personnel blinded.
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Unclear whether outcomes assessors blinded.
Incomplete outcome data (attrition bias)
All outcomes Unclear risk No details of dropouts or whether intention‐to‐treat analysis was used.
Selective reporting (reporting bias) Unclear risk Abstract so unable to assess if all outcomes used in methods were reported in results. 
Other bias Unclear risk Did not state inclusion or exclusion criteria, neither did they describe the methods of statistical analysis used.