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. 2022 Aug 9;2022(8):CD002768. doi: 10.1002/14651858.CD002768.pub5

Selvadurai 2002.

Study characteristics
Methods Design: single‐centre, parallel RCT; hospital admission for recurrent chest infections
Location: Royal Alexandra Hospital for Children, Sydney, Australia
Inclusion criteria: children with CF, aged 8–16 years who were admitted to the Royal Alexandra Hospital for Children for the treatment of an infectious pulmonary exacerbation
Exclusion criteria: children with known pulmonary hypertension, or who required daytime oxygen prior to the pulmonary exacerbation that led to the hospital admission
Participants 66 children with CF (28 boys, 38 girls). No dropouts
Group demographics
Intervention group 1: aerobic exercise training (n = 22): mean age 13.2 (SD 2.0) years, 9 boys and 13 girls
Intervention group 2: resistance exercise training (n = 22): mean age 13.1 (SD 2.1) years, 10 boys and 12 girls
Control group (n = 22): mean age 13.2 (SD 2.0) years, 9 boys and 1 girl
Interventions Short‐term aerobic and anaerobic/strength training study during hospital admission (mean duration 18.7 days, range 14–36 days).
Intervention group 1: 30‐min supervised aerobic exercise training 5 times per week
Intervention group 2: 30‐min supervised resistance training 5 times per week
Control group: no specific training
Outcomes

  1. VO2 peak

  2. VE peak

  3. VCO2

  4. Peak heart rate

  5. HRQoL

  6. FEV1

  7. FVC

  8. Weight

  9. Lower limb strength

  10. Fat‐free mass


Reported at hospital discharge and 1 month after hospital discharge.
Notes  
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Random allocation in sets of 6. No details given for generation of sequence.
Allocation concealment (selection bias) Low risk Concealed information inside opaque envelopes.
Blinding of participants and personnel (performance bias)
All outcomes High risk Not possible to blind participants to intervention. Unclear whether personnel blinded.
Blinding of outcome assessment (detection bias)
All outcomes Unclear risk Unclear whether outcome assessors blinded.
Incomplete outcome data (attrition bias)
All outcomes Low risk Stated no dropouts.
Selective reporting (reporting bias) Unclear risk Did not report on all secondary outcomes detailed in methods (e.g. VE, VCO2, respiratory quotient) in results. Data reported for all time points.
Other bias Low risk Clearly stated inclusion and exclusion criteria.
Described statistical methods used to analyse data.