Figure 5.

(a) Heatmap of lectin microarray data for postvaccination (day 28) serum samples. Columns represent the participants and rows represent the probes. Shown is the normalized log₂ ratios (Sample signal (S)/Reference signal (R)). Total response scores are annotated with a green-white sliding scale bar on the top of the heatmap. Rough specificities of select lectins are annotated on the right of the heatmap. (b,c) Boxplots of log₂ fold-change for paired d28 and d0 samples in non- and high responders. (b) High-mannose binding lectins (Griffithisin and BanLec^H84T). (c) Sialyl Lewis X binding probes (Anti-sLe^x). Paired Mann–Whitney U test was used to determine p-values. n.s.: not statistically significant (no difference is observed d28/d0); (*) p < 0.05. Glycans are shown in SNFG notation at the side of the boxplots. Symbols are defined as follows: galactose (yellow ●), N-acetylglucosamine (blue ■), mannose (green ●), sialic acid (purple ◆), fucose (red ▲).