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. Author manuscript; available in PMC: 2022 Aug 9.
Published in final edited form as: J Alzheimers Dis. 2010;20(Suppl 1):S35–S49. doi: 10.3233/JAD-2010-1400

Fig. 1.

Fig. 1.

Caffeine targets in the striatal spine modules of the GABAergic enkephalinergic neuron (a) and GABAergic dynorphinergic neuron (b). Adenosine A2A-dopamine D2 receptor heteromers are localized in the dendritic spines of the GABAergic enkephalinergic neuron and adenosine A1-dopamine D1 receptor heteromers are localized in the dendritic spines of the GABAergic dynorphinergic neurons. Presynaptic A2A receptors form heteromers with A1 receptors and are localized in the striatal glutamatergic terminals that make contact with the dendritic spines of the GABAergic dynorphinergic neuron. A1 receptors are also localized in a fraction of dopaminergic terminals (modified from ref. [16]).