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. 2022 Aug 9;20:176. doi: 10.1186/s12915-022-01381-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — SAXS patterns and DENSS analysis of holo-CaM in the absence and in the presence of CDZ. A Scattering patterns of holo-CaM (blue trace) and holo-CaM:CDZ complex (red trace). B Distance distribution function P(r) of holo-CaM in the absence and in the presence of CDZ using GNOM, same color code as in panel A. C Dimensionless Kratky representation of holo-CaM in the absence and in the presence of CDZ, same color code as in panel A. Dash lines crossing x-axis (√3) and y-axis (1.104) indicate the characteristic peak for globular proteins. D, E DENSS models of holo-CaM and holo-CaM:CDZ, respectively