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. 2022 Aug 9;23:173. doi: 10.1186/s13059-022-02740-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Single-cell Hi-C revealed that leukemia fusion partner genes are closer to each other in the nucleus. A Heatmap of spatial distances of different fusion gene pairs across single cells. Rows represent fusions, and columns represent different cells. B Comparison of average and minimum Euclidean distance (EuD) values of fusion gene pairs between leukemia, solid tumors, and control. C Comparison of the colocalization ratios of fusion partners between leukemia, solid tumors, and controls. D, E The spatial locations of BCR and ABL1 alleles in the 3D nucleus of two single cells (GM12878 cell 15 and PBMC cell 18), both paternal and maternal alleles, are marked. The statistical tests in B and C are Wilcoxon rank-sum test