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. 2022 Aug 9;23:173. doi: 10.1186/s13059-022-02740-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — SPRITE verified that leukemia fusion partners are in close proximity. A Correlation between the spatial distances of fusion partners measured using single-cell Hi-C and the number contacts measured using SPRITE (more contacts mean closer spatial distance). For the Hi-C data, both average and minimum values over single cells are used. B Fusion partners exhibit higher numbers of SPRITE contacts than control (Wilcoxon rank-sum test). C GSEA results indicate that KMT2A partners are significantly enriched in regions closer to KMT2A (P-value=0.009)