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. 2022 Aug 9;23:173. doi: 10.1186/s13059-022-02740-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5. — KMT2A fusion complex rearrangement related genes (CRGs) are colocalized with KMT2A and partner genes better than control. A An example of complex rearrangements (CRs) involving KMT2A, AFF1, and PDE6C. B Comparisons of CR tightness between CRGs and control for three fusions KMT2A-AFF1, KMT2A-MLLT3, and KMT2A-MLLT10. The smaller the CR tightness score, the closer the genes. C CRGs are more often colocalized with KMT2A and fusion partners simultaneously than control genes; the y-axis shows the percentage of genes that are co-localized with KMT2A and fusion partners simultaneously