Table 3.

Univariate and multivariate Cox regression analysis of overall survival in 126 HCC patients

	Overall survival
Variables	HR	95% CI	P value
Univariate analysis
Age (y, ≤ 60/ > 60)	3.385	1.829–2.264	< 0.001***
Gender	1.197	0.662–1.162	0.552
AFP (ng/ml, ≤ 20/ > 20)	2.378	1.334–4.238	0.003**
Cirrhosis	2.906	1.608–5.251	< 0.001***
HBV	1.132	0.512–2.502	0.760
Tumor size (cm, ≤ 5/ > 5)	2.998	1.596–5.633	0.001**
Pathological stage	0.309	0.167–0.570	< 0.001***
Intrahepatic metastasis	2.942	0.867–9.984	0.084
STAG3 expression	0.114	0.048–0.272	< 0.001***
Multivariate analysis
Age (y, ≤ 60/ > 60)	1.994	0.972–4.090	0.060
AFP (ng/mL, ≤ 20/ > 20)	1.000	0.516–1.940	1.000
Cirrhosis	1.398	0.670–2.916	0.372
Tumor size (cm, ≤ 5/ > 5)	1.025	0.511–2.055	0.944
Pathological stage	0.394	0.195–0.797	0.010*
STAG3 expression	0.174	0.063–0.483	0.001**

CI confidence interval, HR hazard ratio, HCC hepatocellular carcinoma.

*P < 0.05, **P < 0.01, ***P < 0.001.