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. Author manuscript; available in PMC: 2022 Aug 9.
Published in final edited form as: Methods Mol Biol. 2022;2507:375–387. doi: 10.1007/978-1-0716-2368-8_20

Table 1:

SMA, SMI and DIBMA commercial polymers used in the screen

Commercially available polymer Subunit Ratio MW (g/mol) Source company Prior applications
SMALP 140-I S, MI 1.4:1 5000 Cube Biotecha, Orbiscopeb [16]
SMALP 300 S, MA 3:1 10,000 Cube Biotech, Orbiscope [8, 29, 30, 35, 36]
SMALP 200 S, MA 2:1 6500 Cube Biotech, Orbiscope [5, 6, 9–11, 34, 37–39]
SMALP 140 S, MA 1.4:1 5000 Cube Biotech, Orbiscope [37]
DIBMA 10 DIB, MA 1:1 10,000 Cube Biotech n/a
DIBMA 12 DIB, MA 1:1 12,000 Cube Biotech [4, 18, 31, 32]
DIBMA Glycerol DIB, MAGlyc 1:1 10,000 Cube Biotech n/a
DIBMA Glucosamine DIB, MAGluc 1:1 >15,000 Cube Biotech n/a
Glyco-DIBMA DIB, MAGlyco 1:1 15,701c Glycon Biochemicals [33]
a

Polymers supplied by Cube Biotech are in powder form. DIBMA polymers from this vendor are buffered with HEPES or Tris to pH 7.5.

b

Orbiscope offers SMA polymers as 20% w/v solutions in water.

c

Molecular weight as reported by the Glycon Biochemicals certificate analysis. Most of the listed vendors supply the ready-to-use acid form of SMA and DIBMA polymers. Sigma cells the pre-hydrolyzed styrene maleic anhydride (SMAnh) copolymers, which can be chemically converted in-house to the SMA final product (25, 27). Several different molecular weights of DIBMA are commercially available: Cube Biotech offers 10 kDa and 12 kDa versions, while Anatrace and BASF provide a 15.3 kDa version of DIBMA.