Table 4.

Odds Ratios for Moderate/Severe Cognitive Impairment in CKD Adjusted for eGFR and UACR

Risk Factors included in Models	Unadjusted Models All CKD N = 418–436		Adjusted Model All CKD (eGFR < 60) N = 411
	OR (95% CIa)	p-value	OR (95% CIa)	p-value	FDRb adjusted p-value
Age (10-year increase)	1.11 (0.90, 1.36)	0.33	1.32 (1.00, 1.74)	0.05	0.31
Gender: Male vs Female	1.34 (0.89, 2.02)	0.16	1.48 (0.89, 2.47)	0.13	0.46
Years of Education (1-year increase)	0.93 (0.86, 1.003)	0.06	0.98 (0.90, 1.07)	0.63	0.95
Black Race	3.32 (1.97, 5.59)	< 0.001	3.14 (1.50, 6.55)	0.002	0.04
Diabetes c	1.15 (0.77, 1.74)	0.50	0.91 (0.55, 1.52)	0.72	0.99
Stroke / TIA d	2.10 (1.28, 3.45)	0.003	1.70 (0.95, 3.04)	0.08	0.36
Smoker e	1.73 (0.92, 3.23)	0.09	1.10 (0.50, 2.40)	0.82	1.00
CVD f	1.67 (1.10, 2.54)	0.02	1.27 (0.78, 2.06)	0.34	0.81
Pulse Pressure (SBP minus DBP)	1.01 (1.00, 1.02)	0.08	1.01 (0.99, 1.02)	0.36	0.83
Low Hemoglobin g	1.29 (0.85, 1.94)	0.227	0.87 (0.51, 1.47)	0.60	0.95
Phosphorous (1 mg/dL increase)	1.39 (1.04, 1.87)	0.03	1.32 (0.91, 1.90)	0.14	0.46
Calcium (1 mg/dL increase)	0.72 (0.50, 1.03)	0.07	1.03 (0.65, 1.63)	0.90	1.00
PTH (100 pg/mL increase)	1.03 (0.94, 1.14)	0.53	1.04 (0.93, 1.16)	0.49	0.85
Low Bicarbonate (CO2 <20 mEq/L)	2.05 (0.89, 4.71)	0.09	1.63 (0.62, 4.27)	0.32	0.80
Cholesterol (10 mg/dL decrease)	1.02 (0.97, 1.07)	0.49	0.99 (0.93, 1.05)	0.66	0.95
TNF αR1 (1000 pg/mL increase)	1.27 (1.05, 1.53)	0.01	1.40 (1.02, 1.93)	0.04	0.26

^aCI refers to Confidence Interval;

^bFalse Discovery Rate;

^cDiabetes defined as Glucose ≥200 or A1c% ≥6.5 or DM meds or self-report;

^dStroke or TIA (history of) from QVSFS;

^eSmoker: any cigarettes in past month;

^fCardiovascular disease (CVD): history of MI, angina, CHF or peripheral vascular disease;

^gWHO definition for low hemoglobin: <13 g/dL for men, <12 g/dL for women