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. 2022 Jul 26;12:919108. doi: 10.3389/fonc.2022.919108

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Copyright © 2022 Cheng, Zhang, Wan, Zhou, Wu, Fan, He, Tan and Deng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CEMIP promotes the growth and metastasis through Notch signaling pathway. (A, B) Western blot and their quantitative analysis of silencing CEMIP on expression of Notch1, Jagged1 and Hes1 in HOS cells. (C, D) Western blot and their quantitative analysis of silencing CEMIP on expression of Notch1, Jagged1 and Hes1 in U2OS cells. (E–G) Western blot and their quantitative analysis of CEMIP, Notch1, Jagged1 and Hes1 in tumor tissues from two groups of xenograft tumors. (H) Immunohistochemical analysis of Notch1, Jagged1 and Hes1 in osteosarcoma tissue from two groups of xenograft tumors. **P < 0.01, ***P < 0.001. ns, no significance.